Volledig artikel
Endocrine Society
The Journal of Clinical Endocrinology & Metabolism
Familial Longevity is Associated with Higher TSH secretion and Strong TSH-fT3 Relationship
Steffy Jansen1, Ferdinand Roelfsema2, Evie van der Spoel1, Abimbola Akintola1, Iris Postmus1, Bart Ballieux3, P. Eline Slagboom4, Christa Cobbaert3, Jeroen van der Grond5,6, Rudi Westendorp1,7, Hanno Pijl2, and Diana van Heemst1,
Address all correspondence and requests for reprints to: Diana van Heemst, PhD,
Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
, Phone: +31–071-5 266 640, Fax: +31–071- 5 248 159, e-mail: D.van_Heemst@lumc.nl.
DOI: http://dx.doi.org/10.1210/jc.2015-2624
Received: June 19, 2015
Accepted: July 27, 2015
First Published Online: July 31, 2015
Abstract
Context:
Longevity is associated with changes in circulating levels of thyroid hormone (TH) and/or thyroid stimulating hormone (TSH) in animals and humans, but underlying mechanisms remain elusive.
Objective:
We explored in 38 offspring of nonagenarian participants from the Leiden longevity study, who are enriched for longevity and in their partners, ultradian and circadian rhythmicity of TSH, temporal relationship and feedback and forward interplay between TSH and TH.
Methods:
We collected blood samples every 10 min for 24-h TSH and TH profiles. We used deconvolution analysis to estimate basal (non-pulsatile), pulsatile and other secretion parameters to characterize ultradian rhythmicity and locally weighted polynomial regression of TSH to assess circadian rhythmicity. Cross-correlation analysis was employed to investigate the temporal relationship between TSH and TH and cross- approximate entropy (ApEn) to assess feedback and forward interplay between TSH and TH.
Results:
Compared to partners, offspring displayed higher mean (95% - confidence interval (CI)) basal TSH secretion (34.3 (27.2–43.1) mU/L/24 h versus 18.5 (14.4–23.7) mU/L/24 h, P = 0.001), but no differences in ultradian or circadian properties of TSH. Temporal relationship between TSH and fT3 at zero delay was higher in offspring (0.48 ± 0.2) compared to partners (0.26 ± 0.4) (P = 0.05), but feedback and forward interplay between TSH and TH did not differ.
Conclusions:
Familial longevity is associated with increased basal TSH secretion and a strong temporal relationship between TSH and fT3, but not with differences in ultradian or circadian TSH rhythmicity or feedback and forward interplay between TSH and TH.
Volledig artikel:
http://press.endocrine.org/doi/pdf/10.1210/jc.2015-2624
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